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Testosterone Gel

Item Name- Price
Testosterone Gel - Cernos Gel 1% by Sun Pharma

Testosterone Gel - Cernos Gel 1% by Sun Pharma

Testosterone Gel - Cernos Gel 1% by Sun Pharma ONE ORDER UNIT INCLUDES: 1 sachet containing 10 mg mg PER SACHET: 10 mg TOTAL SACHETS PER ONE ORDER...
EUR 4.00

Testosterone gel profile:

Cernos Gel is a transdermal hydroalcoholic Testosterone gel that contains a 1% concentration of Testosterone by weight. The Cernos Gel prescribing information states that the product has a trans dermal bio availability of approximately 10%. This means that each 1 gram dose will deliver approximately 1 mg of hormone systemically. With this mode of administration, Testosterone levels begin to elevate approximately 30 minutes after the gel is applied to the body, and substantial elevations in serum androgen levels are achieved within 4 hours. Testosterone levels will remain elevated for approximately 24 hours after administration, so that that the drug is applied once per day. Regular dosing will provide a steady hormone balance over each 24-hour period. For physique or performance enhancing purposes the most common dose here is 20 grams per day, which delivers approximately 20 mg of testosterone. This level is sufficient for most users to notice significant gains in muscle size and strength. Testosterone is not recommended for women for physique or performance enhancing purposes due to its strong androgenic nature and tendency to produce Virilizing side effects.

Testosterone Gel description:

AndroGel was developed in the United States by Unimed Pharmaceuticals, a division of Solvay. AndroGel was approved by the FDA for sale as a prescription drug in February of 2000. AndroGel is indicated for use in adult males with conditions associated with a deficiency or absence of endogenous Testosterone. This includes cases of primary hypogonadism, which may be caused by cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchectomy, Klinefelterĺs syndrome, chemotherapy, or alcohol/heavy metal toxicity. It is also prescribed to treat hypogonadotropic hypogonadism, including patients with luteinizing hormone or luteinizing hormone-releasing hormone (LHRH) deficiency caused by tumors, injury, or radiation. Primary hypogonadism is usually characterized by low Testosterone and high gonadotropin (LH/FSH) levels, while hypogonadotropic hypogonadism is usually associated with low Testosterone and low to normal gonadotropin levels. AndroGel is said to have a clinical success rate of 87%, perhaps owing to the greater patient comfort and compliance this form of Testosterone offers in comparison with hormone injections. Other transdermal Testosterone hydroalcoholic gels have been released in the U.S. and abroad since the introduction of AndroGel. Testim by Auxilium Pharmaceuticals i perhaps the most well-known competing brand, sold widely in the U.S. and Europe. This product also comes in the form of a 1% Testosterone gel claiming a 10% level of bio availability. Studies have demonstrated that Testim delivers as much as 38% more free Testosterone for a give dose compared to AndroGel, however. Testim is noted to use a thicker and stickier gel compared to AndroGel, which may explain the greater transfer of hormone. In January 2006, the FDA approved the first generic Testosterone gel in the U.S., made by Watson Pharmaceuticals. Testosterone gels are one of the most popular methods of Testosterone delivery in clinic medicine at the present time, and are likely to be soon found in every market globally that supports an acts hormone replacement therapy industry.

Hydroalcoholic transdermal Testosterone gels are available in many human drug markets. Composition and dosage may vary by country and manufacturer, but usually contain 1% Testosterone by weight; packaged in volume tubes of single-dose packets containing 2.5 grams or 5 grams of gel, AndroGel (U.S.) is also produced in a pump dispenser containing 75 grams of gel, which delivers 60 meters applications of 1.25 grams each.

AndroGel is a hydroalcoholic gel containing 1% d Testosterone (free) by weight. It is designed to provide a continuous transdermal delivery of Testosterone for 21 hours following application to the skin. Approximately 1O% of the applied dose is absorbed across the skin during each 24 hour period.

Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of Testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. Exceeding therapeutic doses will increase the likelihood of estrogenic side effects. In such cases, an anti-estrogen such as clomiphene citrate or tamoxifen citrate is commonly applied to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex (Anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.

Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Exceeding normal therapeutic doses is likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Women are warned of the potential Virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as Testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of Testosterone is dependent on its reduction to dihydro Testosterone (DHT). The S-alpha reductase enzyme is responsible for this metabolism of Testosterone. The concurrent use of a S-alpha reductase inhibitor such as Finasteride or Dutasteride will interfere with site-specific potentiation of Testosterone action, lowering the tendency of Testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of Testosterone's anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.

Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of Testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-aminotransferase, and alkaline phosphatase.

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Therapeutic doses of Testosterone used to correct insufficient androgen production in otherwise healthy aging men are unlikely to increase atherogenic risk, and may actually reduce the risk of cardiovascular mortality. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous Testosterone production. Testosterone is the primary male androgen, and offers strong negative feedback on endogenous Testosterone production.Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of Testosterone-stimulating substances, Testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotropic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Testosterone hydroalcoholic gel is applied daily (preferably in the morning) to intact, clean, dry skin of the shoulders, upper arms, and/or abdomen. Patients should be careful about transferring Testosterone to their female partner(s). The prescribing information for AndroGel suggests that patients wash their hands immediately with soap and water after application, and also recommends covering the application site(s) with clothing after the gel has dried. Studies with AndroGel have demonstrated that female partners of male patients noticed as much as a doubling of serum Testosterone levels following 15 minutes of rigorous skin-on-skin contact.This contact was initiated between 2 and 12 hours after drug administration. Testosterone transfer was completely avoided when the male subjects wore a shirt. To treat androgen insufficiency, the prescribing guidelines for AndroGel recommend initiating therapy with a 5g daily dose (delivering 5 mg of Testosterone systemically). Serum Testosterone levels are measured after 14 days, at which point the physician may adjust upwards to 7.5g or 10g if necessary. For physique-or performance enhancing purposes, higher doses would be necessary to achieve supra physiological levels of Testosterone. The most common dose here is 20 grams per day, which delivers approximately 20 mg of Testosterone. This level is sufficient for most users to notice significant gains in muscle size and strength. Lower doses are also regularly used by some athletes, but typically when accompanied by other anabolic/androgenic steroids. Testosterone is ultimately very versatile, and can be combined with many other anabolic/androgenic steroids to tailor the desired effect. Hydroalcoholic transdermal Testosterone gels are not FDA approved for use in women. Testosterone is not recommended for women for physique-or performance enhancing purposes due to its strong androgenic nature and tendency to produce Virilizing side effects.

Given their high relative price and low delivery of Testosterone, hydroalcoholic transdermal Testosterone gels are not commonly traded on the black market. Counterfeits have not yet been widely reported. The various AndroGel, Cernos and Testim preparations can probably be considered real if located.

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